Modulation of the powder properties of lamotrigine by crystal forms

The mechanical properties of powders determine the ease manufacture and ultimately quality oral solid dosage forms. Although poor an active pharmaceutical ingredient (API) can be mitigated by using suitable excipients in a formulation, effectiveness that approach is limited for high dose drugs or multidrug tablets. In this context, improving APIs through form optimisation good strategy to address such challenge. This work explores powder tableting various lamotrigine (LAM) forms with aim facilitate direct compression overcoming tabletability LAM. two drug-drug crystals LAM nicotinamide valproic acid demonstrate superior flowability over improved are rationalised structure analysis energy framework, scanning electron microscopy, Heckel analysis.